LymphedemaV1, Main, Exploration, bibRecord, 002E15

A recombinant human hyaluronidase sustained release gel for the treatment of post-surgical edema.

Identifieur interne : 002E15 ( Main/Exploration ); précédent : 002E14; suivant : 002E16

A recombinant human hyaluronidase sustained release gel for the treatment of post-surgical edema.

Auteurs : Tara Nekoroski [États-Unis] ; Rudolph D. Paladini ; Daniel N. Sauder ; Gregory I. Frost ; Gilbert-A Keller

Source :

International journal of dermatology [ 1365-4632 ] ; 2014.

RBID : pubmed:24168080

Descripteurs français

KwdFr :
- Analyse de variance, Animaux, Attribution aléatoire, Cicatrisation de plaie (), Cicatrisation de plaie (physiologie), Complications postopératoires (diagnostic), Complications postopératoires (traitement médicamenteux), Facteurs temps, Hyaluronoglucosaminidase (usage thérapeutique), Injections intralésionnelles, Lymphoedème (traitement médicamenteux), Lymphoedème (étiologie), Modèles animaux de maladie humaine, Préparations à action retardée (usage thérapeutique), Recombinaison génétique, Résultat thérapeutique, Soins postopératoires, Soins préopératoires, Souris, Valeurs de référence.
MESH :
- diagnostic : Complications postopératoires.
- physiologie : Cicatrisation de plaie.
- traitement médicamenteux : Complications postopératoires, Lymphoedème.
- usage thérapeutique : Hyaluronoglucosaminidase, Préparations à action retardée.
- étiologie : Lymphoedème.
- Analyse de variance, Animaux, Attribution aléatoire, Cicatrisation de plaie, Facteurs temps, Injections intralésionnelles, Modèles animaux de maladie humaine, Recombinaison génétique, Résultat thérapeutique, Soins postopératoires, Soins préopératoires, Souris, Valeurs de référence.

English descriptors

KwdEn :
- Analysis of Variance, Animals, Delayed-Action Preparations (therapeutic use), Disease Models, Animal, Hyaluronoglucosaminidase (therapeutic use), Injections, Intralesional, Lymphedema (drug therapy), Lymphedema (etiology), Mice, Postoperative Care, Postoperative Complications (diagnosis), Postoperative Complications (drug therapy), Preoperative Care, Random Allocation, Recombination, Genetic, Reference Values, Time Factors, Treatment Outcome, Wound Healing (drug effects), Wound Healing (physiology).
MESH :
- chemical , therapeutic use : Delayed-Action Preparations, Hyaluronoglucosaminidase.
- diagnosis : Postoperative Complications.
- drug effects : Wound Healing.
- drug therapy : Lymphedema, Postoperative Complications.
- etiology : Lymphedema.
- physiology : Wound Healing.
- Analysis of Variance, Animals, Disease Models, Animal, Injections, Intralesional, Mice, Postoperative Care, Preoperative Care, Random Allocation, Recombination, Genetic, Reference Values, Time Factors, Treatment Outcome.

Abstract

Edema commonly accompanies surgical procedures and when excessive, can adversely affect surgical outcomes. The skin extracellular matrix, including one of its primary components, hyaluronan (HA), is a significant barrier to effective drainage of accumulated edematous fluid. Recombinant human hyaluronidase (rHuPH20) is a human hyaluronidase that acts transiently and locally to depolymerize HA. A non-liposomal gel formulation that provides a sustained release of rHuPH20 was tested in vivo in a preclinical murine model of acquired lymphedema.

DOI: 10.1111/ijd.12304
PubMed: 24168080

Affiliations:

Le document en format XML

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<term>Hyaluronoglucosaminidase (therapeutic use)</term>
<term>Injections, Intralesional</term>
<term>Lymphedema (drug therapy)</term>
<term>Lymphedema (etiology)</term>
<term>Mice</term>
<term>Postoperative Care</term>
<term>Postoperative Complications (diagnosis)</term>
<term>Postoperative Complications (drug therapy)</term>
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<term>Cicatrisation de plaie (physiologie)</term>
<term>Complications postopératoires (diagnostic)</term>
<term>Complications postopératoires (traitement médicamenteux)</term>
<term>Facteurs temps</term>
<term>Hyaluronoglucosaminidase (usage thérapeutique)</term>
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<term>Recombination, Genetic</term>
<term>Reference Values</term>
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<term>Facteurs temps</term>
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<front><div type="abstract" xml:lang="en">Edema commonly accompanies surgical procedures and when excessive, can adversely affect surgical outcomes. The skin extracellular matrix, including one of its primary components, hyaluronan (HA), is a significant barrier to effective drainage of accumulated edematous fluid. Recombinant human hyaluronidase (rHuPH20) is a human hyaluronidase that acts transiently and locally to depolymerize HA. A non-liposomal gel formulation that provides a sustained release of rHuPH20 was tested in vivo in a preclinical murine model of acquired lymphedema.</div>
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<name sortKey="Paladini, Rudolph D" sort="Paladini, Rudolph D" uniqKey="Paladini R" first="Rudolph D" last="Paladini">Rudolph D. Paladini</name>
<name sortKey="Sauder, Daniel N" sort="Sauder, Daniel N" uniqKey="Sauder D" first="Daniel N" last="Sauder">Daniel N. Sauder</name>
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<country name="États-Unis"><region name="Californie"><name sortKey="Nekoroski, Tara" sort="Nekoroski, Tara" uniqKey="Nekoroski T" first="Tara" last="Nekoroski">Tara Nekoroski</name>
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A recombinant human hyaluronidase sustained release gel for the treatment of post-surgical edema.

A recombinant human hyaluronidase sustained release gel for the treatment of post-surgical edema.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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